In the course of this project, we supported the regional Managing Authority in the implementation of the Smart Specialisation Strategy and the operationalization of the Entrepreneurial Discovery Process. In this regard, we coordinated a series of thematic workshops that brought together actors coming from all wings of the triple helix (business, academia, policy) and engaged them in idea generation and knowledge exchange activities with an innovation-driven perspective. This bottom-up process allowed us to identify many opportunities that emerged through the participants’ interaction, in order to align them to policy measures according to the rationale of Smart Specialisation. Following an in-depth assessment of the workshops’ outcomes, we assisted the Managing Authority of the Region in priority-setting and mobilizing public resources so as to facilitate the realization of this growth potential within the regional innovation territory.